Spravato vs. Ketamine: Understanding Key Differences

Spravato vs. Ketamine: Understanding Key Differences

When it comes to treating depression, understanding the difference between Spravato vs. ketamine is crucial. With FDA approval and insurance coverage, Spravato is the safer, more accessible choice.

In recent years, ketamine has gained attention as a promising treatment for depression. However, many people are unaware of the critical differences between Spravato (esketamine) vs. ketamine infusions—especially when it comes to safety, effectiveness, and insurance coverage.

If you’re considering alternative treatments for depression, it’s essential to understand why Spravato is the better option for many patients.

In this post, we’ll highlight some of the key features of Spravato vs. ketamine:

Spravato vs. ketamine: What’s the difference?

Both Spravato (esketamine) and ketamine target the brain’s glutamate system, a different approach from traditional antidepressants. However, there are significant distinctions:

  • FDA approval & regulation: Spravato is FDA-approved for treatment-resistant depression and major depressive disorder with suicidal ideation. Ketamine infusions, on the other hand, are considered an off-label treatment and are not FDA-approved for depression.
  • Administration method: Spravato is a nasal spray administered under medical supervision in a certified treatment center, while ketamine is typically given as an IV infusion in outpatient clinics.
  • Insurance coverage: Most insurance plans cover Spravato treatments, significantly reducing out-of-pocket costs. Ketamine infusions are no longer covered by insurance, making them a costly option for many patients.
  • Safety & monitoring: Spravato is administered under strict medical supervision, with patients monitored for at least two hours after treatment. Ketamine infusions may not always involve the same level of oversight, increasing potential risks.

Why choose Spravato vs. ketamine?

  1. More affordable & accessible: Since insurance covers Spravato, more patients can access treatment without high out-of-pocket costs.
  2. Proven safety & efficacy: Extensive clinical trials have demonstrated Spravato’s effectiveness in reducing depressive symptoms, leading to its FDA approval.
  3. Consistent medical oversight: Each Spravato treatment session includes professional monitoring, ensuring patient safety and a structured approach to care.

How to start Spravato treatment

If you’re struggling with depression and considering ketamine-based therapy, Spravato offers a safer, more accessible alternative.

Don’t let depression hold you back. Contact us today to learn more or schedule an evaluation.


Ready to learn more about the Spravato treatment process?

Fill out the form at the bottom of this page, and Beth, our Spravato Coordinator, will get in touch within 1 business day. (You can also email us at spravato@sonderwellness.com or call us at 952-999-6097, option 1.)