These results suggest that this practical TMS protocol can effectively address severe depression, providing hope for those who have not benefited from traditional therapies.
Transcranial magnetic stimulation (TMS) has emerged as an effective treatment for individuals suffering from treatment-resistant major depressive disorder (MDD).
Recently, an innovative approach known as the Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) has shown promise, but logistical and financial barriers limit its widespread adoption.
In light of this need for a more accessible treatment regimen, Sonder conducted a new pilot study to evaluate an accelerated iTBS (intermittent Theta Burst Stimulation).
Here are 5 key findings from Sonder’s pilot study of accelerated TMS treatment:
1. Significant reduction in depression symptoms
The pilot study demonstrated a marked decrease in depression scores among participants. Scores on the Montgomery Åsberg Depression Rating Scale (MADRS) showed substantial improvement, with participants experiencing a large effect by the 4-week follow-up.
This indicates that the 5-day accelerated treatment can produce rapid and lasting reductions in depressive symptoms.
2. High rates of response and remission
Following the 5-day treatment, 70% of participants showed a response (≥50% reduction in MADRS scores), while 55% achieved remission (MADRS score ≤9).
These results suggest that this practical TMS protocol can effectively address severe depression, providing hope for those who have not benefited from traditional therapies.
3. Feasibility and safety of the protocol
The study’s design emphasized practicality, using 36 iTBS sessions spread over 5 consecutive days. Despite the intensive dosing, there were no serious adverse events reported. The most common side effects included minor discomfort during stimulation (15%), headaches (25%), and fatigue (10%).
These findings underscore the feasibility of delivering TMS in a more accelerated format without compromising patient safety.
4. Consistent improvement across treatment days
Participants exhibited consistent decreases in depression and anxiety scores throughout the treatment period, particularly after each session. While the third day showed no further improvement compared to the second day, the overall trend remained positive.
This suggests that there is a cumulative effect of the therapy, which may enhance patient motivation for ongoing treatment.
5. Potential to simplify TMS delivery
The study’s use of scalp anatomical landmarks for coil positioning, rather than complex neuroimaging techniques, presents a simplified approach that could reduce costs and increase accessibility for clinics.
This pragmatic method raises the possibility that effective TMS can be administered without the extensive resources typically required, making treatment more available to a broader population.
Learn more about TMS treatment and psychiatric services & medication management we offer at Sonder.
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